{"id":4152,"date":"2024-06-13T23:03:10","date_gmt":"2024-06-13T23:03:10","guid":{"rendered":"https:\/\/avigan.hn\/?p=4152"},"modified":"2024-06-14T20:33:14","modified_gmt":"2024-06-14T20:33:14","slug":"aenean-rutrum-dolor-nibh","status":"publish","type":"post","link":"https:\/\/avigan.hn\/?p=4152","title":{"rendered":"BioCholine\u00ae: Una fuente natural de colina"},"content":{"rendered":"

En los sistemas intensivos de producci\u00f3n animal, la colina se suplementa de manera com\u00fan en las dietas con la finalidad de mejorar la productividad y salud de los animales. La fuente com\u00fan utilizada, es la fuente sint\u00e9tica o en forma de sales de colina, la cual puede representan tambi\u00e9n varios desaf\u00edos para los nutricionistas debido a sus caracter\u00edsticas fisco-qu\u00edmicas. El cloruro de colina, tiene una alta capacidad higrosc\u00f3pica que puede mermar su estabilidad, dando lugar a preocupaciones sobre su real aporte en colina pura y los efectos colaterales que puede ejercer sobre la estabilidad de otras vitaminas (alimento y\/o las pre-mezclas). La BioCholine\u00ae es un producto elaborado a partir de ingredientes naturales seleccionados para proporcionar una fuente de colina estable, la cual puede representar una alternativa rentable al cloruro de colina sint\u00e9tica y los estudios que se presentan en esta revisi\u00f3n trataran de validarlo.<\/p>\n

Es un suplemento alimenticio fabricado a base de plantas (directrices ISO \/ GMP), que contiene colina natural altamente biodisponible y estable en su forma conjugada \/ esterificada (fosfatidilcolina, lecitina y equivalentes). Tambi\u00e9n contiene glicerol, inositol y fosfatidil-serina, mol\u00e9culas que desempe\u00f1an un papel importante en el metabolismo, la modulaci\u00f3n enzim\u00e1tica y la bios\u00edntesis de fosfatidilcolina. Es un producto en polvo, con buena fluidez y no es higrosc\u00f3pico.<\/p>\n

Modo de acci\u00f3n de la BioCholine\u00ae<\/strong><\/p>\n

Contiene fosfatidilcolina, una fuente de colina esterifica, conjugada a una mol\u00e9cula de fosfato. Adem\u00e1s, de otros componentes de tipo lecitinas como la fosfatidilinositol y la fosfatidiletanolamina, mol\u00e9culas con una actividad emulsificante que pueden participar tambi\u00e9n en la activaci\u00f3n de receptores celulares del metabolismo y la movilizaci\u00f3n de la grasa.<\/p>\n

Dichos receptores pueden estimular la liberaci\u00f3n de adiponectina, prote\u00edna implicada en la regulaci\u00f3n de la glucosa y la grasa, disminuci\u00f3n de la absorci\u00f3n e incremento en la redistribuci\u00f3n de los \u00e1cidos grasos libres en el h\u00edgado. Participando en la modulaci\u00f3n del metabolismo de l\u00edpidos, e incrementando la redistribuci\u00f3n de grasa en los tejidos. Esto puede explicar por qu\u00e9, pollos de engorde que fueron suplementados con BioCholine\u00ae en el alimento mostraron una reducci\u00f3n de la grasa en el abdomen e h\u00edgado (Chatterjee et al., 2003, Devegowda et al., 2011).<\/p>\n

A diferencia del cloruro de colina que es hidrosoluble y es absorbido a trav\u00e9s de la circulaci\u00f3n portal, la fosfatidilcolina es liposoluble y se absorbe como quilomicrones en la linfa a trav\u00e9s del conducto tor\u00e1cico. Dando como resultado, una entrega diferenciada y redistribuci\u00f3n de las dos formas de colina en los tejidos (National Academy of Science, 1998).<\/p>\n

De La Huerga y Popper (1952), encontraron que s\u00f3lo un tercio de la colina del cloruro de colina puede ser absorbida a nivel del tubo digestivo, y hasta dos tercios pueden ser convertidos en trimetilamina por acci\u00f3n de las bacterias intestinales, trimetilamina que se excreta en la orina dentro de 6 a 12 horas. Cuando se suministr\u00f3 colina en forma de lecitina (fosfatidilcolina), se excreto una menor parte de trimetilamina en la orina entre 12 a 24 horas despu\u00e9s del consumo. Basados en estudios de la cin\u00e9tica de fuentes de colina, Wurtmann et al. (1977), encontraron que el consumo de lecitina oral fue considerablemente m\u00e1s eficaz para incrementar y mantener (curva de la cin\u00e9tica) por mayor tiempo los niveles de colina en el suero, que cantidades equivalentes de cloruro de colina.<\/p>\n

Por el contrario, en el caso de la colina proveniente de la fosfatidilcolina u otras lecitinas se sugiere un valor cercano al 100% de viabilidad (Emmert et al., 1996). As\u00ed, aunque el cloruro de colina contiene una mayor cantidad de colina por kg de producto respecto al contenido en la BioCholine\u00ae gran parte de esta colina no est\u00e1 disponible para el animal.<\/p>\n

En comparaci\u00f3n al cloruro de colina, podr\u00edamos resumir que la BioCholine\u00ae: muestran una mayor biodisponibilidad; diferente v\u00eda de absorci\u00f3n y cin\u00e9tica; y presencia de ingredientes bioactivos (fosfatidilinositol, fosfatidilcolina y fosfatidilserina), con efectos sobre el metabolismo de l\u00edpidos. Todos los factores previamente enumerados podr\u00edan resolver en parte por qu\u00e9 menores dosis de BioCholine\u00ae pueden remplazar dosis de inclusi\u00f3n m\u00e1s elevadas de cloruro de colina en dietas para animales.<\/p>\n

Referencias<\/strong><\/p>\n

Chatterjee, S., Kumar, A., and Sharma, A., 2003. Comparative efficacy of herbal BioCholine\u00ae and synthetic choline chloride (60%) in commercial broilers. Poultry Technology, 3 (12):38-40.<\/p>\n

Chen, Y.J., Young, K.B., Chang, S.H., Tsai, Y.P., Chen, C.C., 2007. Effect of BioCholine\u00ae as a replacement of synethetic choline supplement on the egg laying performance in laying hen. Phytomedica 8:75-81.<\/p>\n

De La Huega and Potter, 1952. Factors influencing choline absorption in the intestinal tract. J. Clin. Invest. 31:598.<\/p>\n","protected":false},"excerpt":{"rendered":"

En los sistemas intensivos de producci\u00f3n animal, la colina se suplementa de manera com\u00fan en las dietas con la finalidad de mejorar la productividad y salud de los animales. 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